Generate Null Conservation TXI Distribution

Generate a null distribution of transcriptomic index values for conservation testing by permuting phylostratum assignments.

Usage

stat_generate_conservation_txis(strata_vector, count_matrix, sample_size)

Arguments

strata_vector

Numeric vector of phylostratum assignments

count_matrix

Matrix of expression counts

sample_size

Number of permutations to generate

Value

Matrix of permuted TXI values for null hypothesis testing

Details

This function creates a null distribution by randomly permuting phylostratum assignments while keeping the expression matrix fixed. This preserves the expression structure while breaking the phylostratum-expression relationship. # Generate null TXI distribution # null_txis <- stat_generate_conservation_txis(strata_vec, expr_matrix, 1000)