Generate a null distribution of transcriptomic index values for
conservation testing by permuting phylostratum assignments.
Usage
stat_generate_conservation_txis(strata_vector, count_matrix, sample_size)
Arguments
- strata_vector
Numeric vector of phylostratum assignments
- count_matrix
Matrix of expression counts
- sample_size
Number of permutations to generate
Value
Matrix of permuted TXI values for null hypothesis testing
Details
This function creates a null distribution by randomly permuting phylostratum
assignments while keeping the expression matrix fixed. This preserves the
expression structure while breaking the phylostratum-expression relationship.
Examples
# Generate null TXI distribution
# null_txis <- stat_generate_conservation_txis(strata_vec, expr_matrix, 1000)
